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Tamoxifen Citrate

History
Tamoxifen Citrate substance is first discovered by Imperial chemical Industries in 1961. Recently, it is commercially known as Nolvadex.   Later, this organization is purchased by the Astrazeneca. There are numerous forms of this substance all over the world, but among them Nolvadex is the most popular and well known among them. World Health Organization has given the approval to this substance currently, as it has immense usage. It is actually regarded as selective Estrogen Receptor Modulator.
 

What is Tamoxifen Citrate?
Tamoxifen Citrate resists the actions and functionality of estrogen, a female hormone.  It is very similar to clomid. This substance is required to treat some types of breast cancer of male and female. It is also used to diminish the chances of breast cancer of women if she has any medical history of cancer in her family.
This is also regarded as medication to many anabolic users, but it is not a steroid. It increases the secretion of testosterone and makes its level normal in blood.

Used as medicine
The main usage as medication of this substance in both early and advanced breast cancer in pre and post menopausal women is immense. It is also benefited for treating male breast cancer and a good substance for successful PCT.  Studies have shown that 66% chances of re occurrences of cancer drops. It also used as a good medication to treat the women’s infertility. It fairly increases the chances the chances of pregnancy almost double. It belongs to the triphenylethylene group.
 

Structural characteristic
Tamoxifen is an antineoplastic non-steroidal selective estrogen receptor modulator that is beneficial for decreasing the factors that increases the growth of breast cells and increases the factors that growth of breast cells. It belongs to the triphenylethylene group.  Such substance generally used to prevent the receptor from binding to the estrogen – response element on DNA. Tamoxifen up- regulates the production of transforming growth factor B (T G F b), a factor that controls the tumor cell growth.

Side Effects (Hepatotoxicity):
The prolonged usage of this medication may have harsher effects on liver as it may responsible for fatty liver.

Side Effects (Cardiovascular):
The Tamoxifen Citrate is associated with benefits of serum lipid profiles of postmenopausal women. But prolonged usage may cause the failure of cardio protective effect. Among women it increases the levels of triglyceride in blood. Apart from that there is a huge chance of thromboembolism especially after the major surgery or periods of immobility.

Additional site effects:
Possible side effects of this medication also exist. The most common side effects that may generally occur include:

·         Vaginal itching, bleeding, discharge or discomfort

·         Hot flashes

·         Stomach problems

·         Headache

The above mentioned side effects are not extremely common but possible. The other possible side effects but less common are as follows:

·         Rash

·         Decreased white blood cell count

·         Endometrial changes

·         Pulmonary Embolism

·         Chest pain, fast heart beats

·         Blurred vision, cataracts in the eyes or other eye problems

·         Cough and fever

·         Lower back or side pain

·         Anxiety

·         Peeling or loosening of the skin and muscle membrane

·         Black, tarry stools

·         Bleeding gums

·         Blood in the urine or stools

·         Bone pain

·         Changes in the sex drive

 
 
Side Effects of Testosterone:
This is the medication that is not responsible for the suppression of male sex hormone testosterone.  But it stimulates the secretion of LH and FSH that accelerates the secretion of testosterone. So users never face the problems of suppression of natural male sex hormone due to its usage.


Administration (Men):
Men should take this medicine with or without food usually once or twice daily for 5 years as recommended by physician. Daily dosage for men should be 20 mgs for men is recommended and this dosage is divided in half and taken in twice a day.  Men should use this substance carefully using a special measuring device.

Administration (Women):

In pre menopausal women suffering from breast cancer may take Tamoxifen Citrate as an alternative to ovarian irradiation. But the dosage should be decided by the physician as per the requirement. But the general dosage is 20 mgs to 40 mgs.

How work Tamoxifen Citrate in human body

·         The Main usage of this substance is in the treatment of both early and advance breast cancer in pre and post menopausal women.

·         Tamoxifen Citrate is also beneficial to control the male breast cancer.

·         Another benefit of using this substance is to cure the infertility. It makes the chances of pregnancy double.

·         It is also used to treat the bipolar disorders.

·         The usage of this supplement stimulates the production of Testosterone by increasing the production of LH and FSH. This helps to go up the levels of this male sex hormone.

·         Tamoxifen Citrate acts as a good medium to make a PCT successful with full recovery.

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